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Multiple human, animal, and cellular studies converge on the view that mitochondrial dysfunction, oxidative stress, and impaired mitophagy lead to leakage of mtDNA into the cytosol and extracellular space, where it activates innate immune sensors and sustains chronic inflammation

M., Doltsinis, N

Effects on osteoclasts and bone resorption On the other side of the equation, MOTS-c inhibits osteoclast differentiation through AMPK-dependent suppression of RANKL signaling

A group of ARSs-associated antibodies, including anti-Jo-1 (anti-HRS), anti-PL7 (anti-TRS), anti-PL12 (anti-AlaRS), anti-OJ (anti-IRS), anti-EJ (anti-GRS), and other less common antibodies, are regarded as a hallmark of ASS (Witt et al., 2016)